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碧姬（艾米莉·帕金斯 Emily Perkins 飾）和金傑（凱瑟琳·伊莎貝爾 Katharine Isabelle 飾）是情同手足的姐妹，彼此之間感情十分親密。某日，金傑外出意外遭到了一隻怪獸的襲擊，好在雖然身受重傷，但好歹撿回了一條性命。然而，令碧姬感到擔心的是，自此金傑的性情大變，日漸放蕩狂野，不僅四處沾花惹草，甚至開始渴望鮮血的滋味。 讓碧姬感到更加恐慌的是，她發現金傑身上已經愈合的傷口之上竟然長出了褐色的毛發，而她的尾椎骨上亦身處了類似尾巴一樣的部分。無法對此坐視不管的碧姬找到了喜歡研究植物的山姆（克裏絲·萊切 Kris Lemche 飾），希望後者能夠研製出解藥，讓金傑變回原樣。
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